Difference between revisions of "Overall circulation model"
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The overall circulation model was created by Guyton and colleagues in 1972<ref>Guyton A. C., Coleman T. G., Granger H. J. Circulation: Overall regulation. Ann. Rev. Physiol. 1972; V. 34:. P. 13-46.</ref>. The model consists of differential-algebraic- equations and demonstrates long-term effects of CVS with significant role of kidney regulation. Despite the fact that a lot of time has passed since the model was published, it is still an object of interest for systems biologists<ref>Osborn J.W., Averina V.A., Fink G.D. Current computational models do not reveal the importance of the nervous system in long-term control of arterial pressure. Exp Physiol 94(4): 381-397, 2009.</ref>. In 2010 it was reconstructed using MATLAB SIMULINK<ref>Kofranek J., J. Rusz. Restoration of Guyton's diagram for regulation of the circulation as a basis for quantitative physiological model development. Physiological Research, 2010, 59(6): 897-908.</ref>. A number of latest global models are also based on Guyton's model. One of such models is the long-term CVS model implemented by Karaaslan and coauthors<ref>Karaaslan F., Denizhan Y.,Kayserilioglu A., Gulcur H.O. Long-term mathematical model involving renal sympathetic nerve activity, arterial pressure, and sodium excretion // Ann. Biomed. Eng. 2005. Vol.33. P.1607 - 1630.</ref>. | The overall circulation model was created by Guyton and colleagues in 1972<ref>Guyton A. C., Coleman T. G., Granger H. J. Circulation: Overall regulation. Ann. Rev. Physiol. 1972; V. 34:. P. 13-46.</ref>. The model consists of differential-algebraic- equations and demonstrates long-term effects of CVS with significant role of kidney regulation. Despite the fact that a lot of time has passed since the model was published, it is still an object of interest for systems biologists<ref>Osborn J.W., Averina V.A., Fink G.D. Current computational models do not reveal the importance of the nervous system in long-term control of arterial pressure. Exp Physiol 94(4): 381-397, 2009.</ref>. In 2010 it was reconstructed using MATLAB SIMULINK<ref>Kofranek J., J. Rusz. Restoration of Guyton's diagram for regulation of the circulation as a basis for quantitative physiological model development. Physiological Research, 2010, 59(6): 897-908.</ref>. A number of latest global models are also based on Guyton's model. One of such models is the long-term CVS model implemented by Karaaslan and coauthors<ref>Karaaslan F., Denizhan Y.,Kayserilioglu A., Gulcur H.O. Long-term mathematical model involving renal sympathetic nerve activity, arterial pressure, and sodium excretion // Ann. Biomed. Eng. 2005. Vol.33. P.1607 - 1630.</ref>. | ||
| − | We have reconstructed it as a modular model in the BioUML framework. The modular model comprises: | + | We have reconstructed it as a [[Modular modeling|modular model]] in the BioUML framework. The modular model comprises: |
229 parameters | 229 parameters | ||
Revision as of 12:18, 7 May 2013
The overall circulation model was created by Guyton and colleagues in 1972[1]. The model consists of differential-algebraic- equations and demonstrates long-term effects of CVS with significant role of kidney regulation. Despite the fact that a lot of time has passed since the model was published, it is still an object of interest for systems biologists[2]. In 2010 it was reconstructed using MATLAB SIMULINK[3]. A number of latest global models are also based on Guyton's model. One of such models is the long-term CVS model implemented by Karaaslan and coauthors[4].
We have reconstructed it as a modular model in the BioUML framework. The modular model comprises:
229 parameters 133 assignments 39 ordinary differential equations
References
- ↑ Guyton A. C., Coleman T. G., Granger H. J. Circulation: Overall regulation. Ann. Rev. Physiol. 1972; V. 34:. P. 13-46.
- ↑ Osborn J.W., Averina V.A., Fink G.D. Current computational models do not reveal the importance of the nervous system in long-term control of arterial pressure. Exp Physiol 94(4): 381-397, 2009.
- ↑ Kofranek J., J. Rusz. Restoration of Guyton's diagram for regulation of the circulation as a basis for quantitative physiological model development. Physiological Research, 2010, 59(6): 897-908.
- ↑ Karaaslan F., Denizhan Y.,Kayserilioglu A., Gulcur H.O. Long-term mathematical model involving renal sympathetic nerve activity, arterial pressure, and sodium excretion // Ann. Biomed. Eng. 2005. Vol.33. P.1607 - 1630.
