Modular model of the human CVS v.1

Overall Circulation modular model

Simulation example: sodium load

Using the modular approach we have created a complex modular model of the human cardiovascular system (CVS) on the basis of:

• Long-term model of the CVS/Renal system by Karaaslan et al.
• Short term model of the heart output regulation cerated by professor Soloyannikov.

The models have the same formalisms - ordinary differential equations with descrete events, however they have different time scales: seconds in the short-term model, minutes in the long-term one. Merge of the models was based on the next two points: The "Heart" and "Arteris" modules from the long-term modular model contain the averaged parameters such as arterial blood pressure or arterial resistance described in more detail by the short-term model, in its turn, the long-term human CVS model contains a blood volume regulation mechanism based on the salt-water balance in the human body, while the short-term model keeps the blood volume parameter at a constant level. The established connections between the modules were taken from different models:

Arterial pressure P_A and cardiac output V_out from the short-term model are passed to the long-term model (after the averaging to avoid systole-diastole oscillations) Blood volume V_Syst is passed to the short-term model