Mapping to ontologies for multiple gene sets (workflow)

Workflow title

Mapping to ontologies for multiple gene sets

Provider

geneXplain GmbH

Workflow overview

Description

This workflow is designed to classify a multiple set of genes by enrichment analysis using GO, Reactome, HumanCyc and TF classification databases. Gene sets should be located in one folder At the first step, the input table is converted into a table with Ensembl Gene IDs.

This table with Ensembl Gene Ids is subjected to functional classification, which is done in parallel by the following ontologies: GO biological processes, GO cellular components, GO molecular functions, Reactome pathways, HumanCyc pathways, TF classification.

For each ontological term several parameters are calculated, including expected number of hits, actual number of hits, p-value, as well as hit names and the link to the corresponding ontological term. 

The same steps are repeated for the next input table, and several cycles are performed automatically corresponding to the number of tables in the input folder.

 

 

Parameters

Input folder

Folder to get input tables from

Species

Results folder

Folder to store results (will be created if not exists yet)