SBGN extension
BioUML fully supports and heavily utilizes SBML (Systems Biology Markup Language) as a standard for description of mathematical models with ODE and discrete events (https://sbml.org/). BioUML also utilizes Visual modeling as one of its core features. Thus each SBML model is represented visually in BioUML interface. Main component of visual modeling is formal graphic notation which defines how particular elements of the model should be represented visually.
The most well known graphical notation in the systems biology is SBGN (Systems Biology Graphic Notation). It has three different versions, here we will concern only with Process description notation which describes the temporal courses of biochemical interactions in a network (https://sbgn.github.io/). It is compatible with SBML although it more relies on pathways comprising of entities and processes between them. Thus it does not cover every single object in SBML models. Particularly there is no visual representations for "mathematical" objects: equations, functions, events, etc.
In BioUML we fully support SBGN Process Description notation, however we decided to extend notation we use in BioUML to fully represent SBML models. Additional motivation for that is the fact that there are many mathematical objects of biological systems (in particular - physiological model) that are not represented by a network of biochemical reactions but rather contain a set of ODE equations. For example:
New elements added to SBGN notation in BioUML
| Name | Notation | Description |
|---|---|---|
dsdd |Mathematical equation in the model:
|
| |} |
